San Antonio AirLIFE is a regional air medical transport provider licensed by the Texas Department of State Health Services. Helicopter transport of the critically ill and injured is available 24 hours a day/365 days a year in a 150 mile radius around San Antonio.

Three Bell 430 helicopters are used to perform both inter-hospital transfers and emergency scene transports in conjunction with local EMS agencies. Requests for air transport are accepted from authorized hospital personnel for transfers of patients from a lower level of care to a higher or equal level of care.

Requests are also accepted from EMS agencies, police and sheriff's departments, and fire department personnel. Flights are accepted without discrimination due to race, creed, sex, color, age, religion, national origin, ancestry, handicap, or ability to pay. Emergency scene responses or requests, in the AirLIFE service area, which involve a patient with a potentially life threatening illness or injury, are accepted without prescreening for the ability to pay.

The AirLIFE medical crew consists of a Registered Nurse/Paramedic team for every patient mission. The medical flight crews provide advanced life support for a wide variety of patients from adult to pediatric age suffering from varied medical diagnosis. Additionally, the AirLIFE medical crews accompany specialty teams from University Hospital, Methodist Children's Hospital, Santa Rosa Children's Hospital, and Wilford Hall Medical Center.

The medical crews performs assessments and intervene with advanced skills when required by written protocols or with the direction of medical control physician. San Antonio AirLIFE also provides transport for organ retrieval teams when aircraft are available. Both San Antonio AirLIFE medical crew members accompany these flights as safety officers.